Guide

Semaglutide Dosage Chart: The Full Titration, and What Each Step Costs

Semaglutide for weight management titrates over 16 weeks: 0.25 mg weekly for four weeks, then 0.5, 1.0, 1.7 and 2.4 mg, each for four weeks. The label states the lower do

What is the dosage schedule?

The flat column is a figure we captured at source. The tiered column is a typical published escalation pattern, shown for comparison rather than attributed to any one provider.

Why is titration needed at all?

Titration is not a marketing device. Gastrointestinal adverse events cluster in the first weeks at each new dose, and stepping up slowly is what makes the drug tolerable. In STEP-1, roughly 44% of participants reported nausea and about 7% discontinued for an adverse event.

The label directs increases every four weeks as tolerated. A provider that escalates on a calendar rather than on tolerability is not following the label, and that is a clinical question worth asking before a pricing one.

What if I cannot tolerate 2.4 mg?

Staying at 1.7 mg is a legitimate clinical outcome and the label allows it. On a flat programme that costs the same as 2.4 mg. On a tiered one it saves you a step.

Microdosing is a different thing. Microdose programmes use doses below 0.25 mg, beneath every dose studied in STEP-1, so no published efficacy figure applies to them at any price. They have real uses — tolerability, maintenance after reaching a goal — but a microdose programme and a full-dose programme are not comparable on price.

Plan totals as published: $447 for three months, $882 for six, $1,740 for twelve. Each reconciles exactly against its monthly rate. The sublingual 3-month plan does not — it states a $597 total against a $185 monthly rate, which multiplies to $555. We record the monthly rate and have asked for the total to be corrected. COR-012.

What is the salt-form question?

Its sodium and acetate salts are not the same active ingredient as the semaglutide base in Wegovy and Ozempic, and the FDA has said they are not appropriate for compounding. A salt form is a different chemical entity; it has not been through the safety or efficacy review the base went through.

Ask for the exact salt form and concentration in writing before you buy. A provider that cannot answer in writing has told you something. There is no tirzepatide equivalent of this question, which is why it belongs on every semaglutide page and on none of the tirzepatide ones.

How does every provider score on the six tests?

Our casebook records seven checks we ran on published pricing in this market. Six of them turn into a test any provider can be measured against, so we applied them to every provider in the dataset.

Frequently asked questions

Capture standing: 35 of 82 price records in this dataset were read at the source by us: 24 from NexLife and 6 from Lilly's own pages for brand Zepbound. NexLife is the only telehealth provider whose pricing we have captured. Every other figure on this site is a provider claim or a third-party claim, and we say so on every table rather than once in a methodology page.