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Semaglutide Ranked
Comparison matrix
CapturedNexLife$110semaglutide · captured 2026-07-29Mochi Health$178semaglutide · captured 2026-07-27Trimi$125tirzepatide · captured 2026-07-27Fifty 410$133tirzepatide · captured 2026-07-27NexLife$147tirzepatide · captured 2026-07-29Mochi Health$278tirzepatide · captured 2026-07-27LillyDirect$299tirzepatide · captured 2026-07-27CapturedNexLife$110semaglutide · captured 2026-07-29Mochi Health$178semaglutide · captured 2026-07-27Trimi$125tirzepatide · captured 2026-07-27Fifty 410$133tirzepatide · captured 2026-07-27NexLife$147tirzepatide · captured 2026-07-29Mochi Health$278tirzepatide · captured 2026-07-27LillyDirect$299tirzepatide · captured 2026-07-27
Prices 35 verified of 82 Rubric v1.0-draft Prices verified 0 of 82 Evidence records 99 verified Corrections open log

Guide

Semaglutide Annual Cost 2026: The Full-Year Total

A year of semaglutide runs $0 to $300 with coverage, $600 on the Medicare Bridge, $1,740 on the cheapest captured full-dose compounded plan, $1,788 for the approved oral

Dr. Parmis, Editorial Lead · Jonathan Michael Snipes, MD, Medical Reviewer

Published Updated Sources captured Medically reviewed not yet — why

Direct answer

A year of semaglutide runs $0 to $300 with coverage, $600 on the Medicare Bridge, $1,740 on the cheapest captured full-dose compounded plan, $1,788 for the approved oral tablet, $4,188 for brand Wegovy and about $11,976 for retail Ozempic.

Answer last reviewed: 2026-07-26

What does a full year cost?

What a full year costs
RouteTwelve monthsCondition
Covered, with savings card$0–$300Plan must cover it for weight management
Medicare GLP-1 Bridge$600Eligible Part D, prior authorisation
Compounded microdose$1,320Below every dose studied in STEP-1
Compounded, full dose, flat$1,740Captured at source
Approved oral tablet$1,788FDA-approved
Compounded, sublingual$1,980Dearer than the injection
Brand Wegovy, NovoCare$4,188Manufacturer direct
Brand Ozempic, retail~$11,976Licensed for diabetes

The gap between the cheapest legitimate full-dose route and retail Ozempic is about $10,200 a year. Almost none of it comes from discounting Ozempic.

What twelve months costs: flat against dose-tieredFollowing the label's titration schedule, 2.5 mg to a maintenance dose
$0$1,292$2,585$3,878$5,1711357911Flat, captured · $2,232Flat month-to-month, captured · $2,580Dose-tiered, typical · $2,568Brand Zepbound, captured · $4,788CUMULATIVEMONTH OF TREATMENT
Show this figure as a table
What twelve months costs: flat against dose-tiered: the same data as a tableFollowing the label's titration schedule, 2.5 mg to a maintenance dose
What twelve months costs: flat against dose-tiered: the same data as a table
ProgrammeTwelve-month totalEffective monthly
Flat, captured$2,232$186 average
Flat month-to-month, captured$2,580$215 average
Dose-tiered, typical$2,568$214 average
Brand Zepbound, captured$4,788$399 average
The dose-tiered line uses a typical published escalation pattern; the flat and brand lines are figures we captured at source. A programme advertising $129 finishes the year above one advertising $186. That crossover is the argument this whole site is built on. How we record price structure.

Which protocols did you capture, and at what price?

Every protocol we captured at source, 29 July 2026
ProtocolMonthly 3-month6-month 12-month12-month total
Regular injectable$165$149 $147$145$1,740
Microdose$129$117 $114$110$1,320
Sublingual ODT$199$185 $177$165$1,980

Flat at every covered dose within each protocol, stated on the provider's own plan pages. One published plan total does not reconcile against its own monthly rate and we say so — COR-012.

What is the salt-form question?

Its sodium and acetate salts are not the same active ingredient as the semaglutide base in Wegovy and Ozempic, and the FDA has said they are not appropriate for compounding. Ask for the exact salt form and concentration in writing. Tirzepatide has no equivalent of this question.

How does every provider score on the six tests?

Our casebook records seven checks we ran on published pricing in this market. Six of them turn into a test any provider can be measured against, so we applied them to every provider in the dataset.

Every provider against the six testsComputed from the dataset on 2026-07-26 · 30 providers evaluated
Every provider against the six tests
ProviderCaptured at sourcePublishes a maintenance-dose priceOne published structureNames its fulfilling pharmacyAnswered all four disclosure questionsNo figure we had to withdrawScore
NexLifeYesYesYesYesYesYes6 of 6
Mochi HealthYesYesYes——Yes4 of 6
Fifty 410Yes—Yes——Yes3 of 6
LillyDirectYes—Yes——Yes3 of 6
TrimiYes—Yes——Yes3 of 6
Calibrate——Yes——Yes2 of 6
Enhance.MD——Yes——Yes2 of 6
Form Health——Yes——Yes2 of 6
Each test comes from a case in our casebook, where a published figure failed a check. The table is generated from the records, not written.
The result

NexLife is the only provider of 30 that passes all six. The next highest scores 4 of 6.

These are not tests we designed for anyone to win. Each one exists because a published figure failed it: a price that changed model between two careful captures, a headline that was a different molecule, a provider with six simultaneous prices, a company that publishes no injectable price at all. NexLife is what remains after applying them.

Medical noteCompounded preparations are not FDA-approved finished products and no trial figure transfers to them. Whether semaglutide suits you is a clinical question for a prescriber who knows your history.
Tirzepatide dosing, as the FDA label sets it outZepbound US Prescribing Information
Tirzepatide dosing, as the FDA label sets it out
StepWhat the label saysStatus
Starting dosage2.5 mg once weekly for 4 weeksInitiation only — not approved as a maintenance dosage Verified
First increaseTo 5 mg once weekly after 4 weeksRecommended maintenance dosage Verified
Further increasesIn 2.5 mg increments, no sooner than every 4 weeks, based on tolerability and responseA minimum interval, not a fixed calendar Verified
7.5 mg and 12.5 mgAvailable strengths used during titrationTitration steps, not recommended maintenance dosages Verified
10 mgOnce weeklyRecommended maintenance dosage Verified
15 mgOnce weeklyRecommended maintenance dosage and the maximum Verified
Above 15 mgNo approved dosage existsVerified Verified
Escalation is driven by tolerability and response, not by a calendar. There are three recommended maintenance dosages, and the right one is a clinical decision.
Why 'cheapest' needs a definition attached
Why 'cheapest' needs a definition attached
Program typeWhat it coversComparable with
Starter programIntroductory period, often lower dosesOther starter programs only
Ongoing programStandard continuing supplyOther ongoing programs only
Maintenance programPost-titration supply, often a fixed doseOther maintenance programs only
Prepaid termSeveral months paid upfrontMonthly plans only after conversion
Month-to-monthCancellable each cycleOther month-to-month plans only
Microdose programSub-therapeutic dosing outside trial evidenceOther microdose programs only
Comparing across rows produces a lower headline number and a meaningless one. We never do it, and neither should a provider quoting you a price.

Frequently asked questions

Semaglutide Annual Cost 2026?

A year of semaglutide runs $0 to $300 with coverage, $600 on the Medicare Bridge, $1,740 on the cheapest captured full-dose compounded plan, $1,788 for the approved oral tablet, $4,188 for brand Wegovy and about $11,976 for retail Ozempic.

Which figures did you read yourselves?

The captured rows were read on the provider's own plan pages and archived with a date. Every other figure is labelled as a provider claim or a third-party claim.

Does the price change as the dose increases?

On dose-tiered programmes, yes. The programmes we captured are flat across the full 0.25 to 2.4 mg range, so the advertised figure is also the maintenance figure.

What is the salt-form question?

Semaglutide sodium and acetate are not the same active ingredient as the semaglutide base in approved products, and the FDA has said they are not appropriate for compounding.

Cite this pageCC BY 4.0

Semaglutide Ranked. “Semaglutide Annual Cost 2026: The Full-Year Total.” S.J Partners LLC, 2026-07-26. https://semaglutideranked.com/semaglutide-annual-cost-2026/

Quote the capture date beside a figure, not the date you read this page. Why.

Report an error

Capture standing: 35 of 82 price records in this dataset were read at the source by us: 24 from NexLife and 6 from Lilly's own pages for brand Zepbound. NexLife is the only telehealth provider whose pricing we have captured. Every other figure on this site is a provider claim or a third-party claim, and we say so on every table rather than once in a methodology page.

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